Liverpool pair James Milner and Kostas Tsimikas have been out of the Reds' crucial Premier League clash with Arsenal because of illness.

The Lowdown: Reds face huge game v Arsenal

Jurgen Klopp's men face one of their biggest matches of the season on Wednesday night, making the trip to face a Gunners side who have taken control of the battle to finish fourth.

Manchester City's 0-0 draw at Crystal Palace on Monday means that Liverpool can get to within one point of their title rivals with a win at the Emirates Stadium, although it will be no easy task.

Mohamed Salah looks set to be available for the game despite suffering a knock away to Brighton last weekend but two other players are missing for the trip to north London.

The Latest: Milner and Tsimikas ruled out

Taking to Twitter on Tuesday, journalist Carl Markham confirmed that Milner and Tsimikas have been ruled out of tonight's clash in north London.

He tweeted: "Klopp says Konate is back fit. Milner and Tsimikas are out with illness."

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The Verdict: Milner's experience will be a miss

While neither Milner nor Tsimikas are regular figures in this magnificent Liverpool team, they have been important squad members this season, starting seven league matches apiece.

In terms of who will be the biggest miss, the English veteran's vast experience could have been so important in a match of such magnitude, coming on in the second half to help manage the game, especially if the Reds are winning at that point.

The hope is that Liverpool still have enough midfield depth to alleviate that issue, both in terms of quality and nous, while Andy Robertson is clearly first-choice over Tsimikas at left-back, so the Greek might not be a devastating miss for one game.

In other news, Liverpool have been linked with a hugely exciting move for one midfielder. Read more here.